George, a 50-year-old male, visited his doctor when he noticed the whites of his eyes appeared yellow and he had dark urine.

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George, a 50-year-old male, visited his doctor when he noticed the whites of his eyes appeared yellow and he had dark urine. His CBC revealed a hemoglobin of 31 g/L.

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Given his clinical description, name at least 2 lab tests that should be ordered to assist in diagnosis?

George’s only complaint was the yellow color of his eyes and dark urine. His CBC:

Hb 3.1 g/dL, Hct 0.08 L/L

RBC count 0.71 × 10¹²/ L

RDW 21.6

Reticulocytes 22%

Calculate the erythrocyte indices.

Question 3: Does the information given support acute or chronic blood loss? What is the significance of the RDW?

George’s RBC count is 0.7 × 10¹²/L and his reticulocyte count is 22%.

Question 4: Calculate his absolute reticulocyte count. Is this count increased, decreased, or normal?

George’s blood smear revealed marked spherocytosis.

Question 5: Explain the importance of this finding.

Question 6: Explain George’s abnormal indices.

Question 7: Classify George’s anemia morphologically.

George had a test done that revealed antibodies and complement coating his red blood cells, this supports a diagnosis of immune hemolytic anemia.

Question 8: Classify George’s anemia functionally.

Question 9: Why were George’s eyes yellow?

Question 10: Was this anemia chronic or acute and why?